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Brain cancer

Not applicable

Rat studies suggest convection-enhanced delivery (CED) of brain-penetrant nanoparticles loaded with dithiazanine iodide could help treat glioblastoma multiforme (GBM). In a human brain cancer stem cell line, the anthelmintic dye dithiazanine iodide inhibited cellular proliferation with an IC50 value of 79 nM.
In a rat xenograft model for human GBM, CED of dithiazanine iodide-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles to the brain significantly increased median survival compared with CED of free dithiazanine iodide or empty nanoparticles (p<0.005). Next steps include evaluating the drug-loaded nanoparticles in a clinical trial.

SciBX 6(30); doi:10.1038/scibx.2013.782
Published online Aug. 8, 2013

Patent application filed covering use of nanoparticle delivery system in CNS indications; available for licensing from Yale University
Contact: Thomas Shrader, Yale University, New Haven, Conn.

Zhou, J. et al. Proc. Natl. Acad. Sci. USA; published online July 1, 2013;
Contact: W. Mark Saltzman,
Yale University, New Haven, Conn.