This week in therapeutics




Licensing status

Publication and contact information

Infectious disease

Chagas disease; malaria; trypanosome

Not applicable

In vitro and mouse studies suggest m-terphenyl and dipyridylbenzene compounds could help treat protozoan infections. In vitro assays identified m-terphenyl and dipyridylbenzene analogs that inhibited the activity of Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum at nanomolar IC50 values. In mouse models for trypanosome infection, several lead compounds increased relapse-free survival compared with the generic antiprotozoal drugs pentamidine and melarsoprol. Next steps could include testing the lead compounds in mouse models for malaria infection.
Pentamidine is approved to treat pneumonia caused by Pneumocystis carinii, and melarsoprol is approved to treat human African trypanosomiasis.

SciBX 6(29); doi:10.1038/scibx.2013.760
Published online Aug. 1, 2013

Patent and licensing status unavailable

Patrick, D.A. et al. J. Med. Chem.; published online June 24, 2013;
Contact: Richard R. Tidwell, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.