This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Breast cancer

Tissue factor

In vitro and mouse studies suggest inhibiting alternatively spliced tissue factor (asTF) could help treat breast cancer. In breast cancer cells implanted into mouse mammary fat pads, cells overexpressing asTF showed greater proliferation and anchorage-independent growth than cells overexpressing full-length TF. In mice implanted with asTF-overexpressing breast cancer cells, an asTF-targeting antibody inhibited proliferation. Next steps could include studies in additional mouse models.

SciBX 6(29); doi:10.1038/scibx.2013.750
Published online Aug. 1, 2013

Unpatented; licensing status unavailable

Kocatürk, B. et al. Proc. Natl. Acad. Sci. USA; published online June 25, 2013;
doi:10.1073/pnas.1307100110
Contact: Henri H. Versteeg, Leiden University Medical Center, Leiden, the Netherlands
e-mail:
h.h.versteeg@lumc.nl