Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Pain

Potassium channel Kv1.2 (KCNA2)

Rat studies suggest targeting KCNA2 antisense long noncoding RNA (lncRNA) could help treat neuropathic pain. In a rat model for neuropathic pain, injured dorsal root ganglion neurons showed greater Kcna2 antisense lncRNA expression and lower Kcna2 protein expression than uninjured nerves. In a rat model for peripheral nerve injury, Kcna2 sense RNA normalized Kcna2 protein levels and decreased neuropathic pain compared with control RNA. Next steps include testing inhibition of Kcna2 lncRNA in animal models for cancer-associated and chronic pain (see Silencing neuropathic pain, page 7).

SciBX 6(28); doi:10.1038/scibx.2013.734
Published online July 25, 2013

Unpatented; licensing status not applicable

Zhao, X. et al. Nat. Neurosci.;
published online June 23, 2013;
doi:10.1038/nn.3438
Contact: Yuan-Xiang Tao, The Johns Hopkins University School of Medicine, Baltimore, Md.
e-mail:
ytao1@jhmi.edu