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Nerve damage

Purinergic receptor P2Y G protein-coupled 1 (P2RY1; P2Y1)

Cell culture studies identified dual-acting antioxidant and P2Y1 receptor agonist nucleotides that could be useful as neuroprotectants. In a human cell line, the lead nucleotide selectively agonized P2Y1 with an EC50 value of 7 nM. In rat neuronal cell lines, the nucleotide reduced reactive oxygen species (ROS) production with an IC50 value of 80 nM. Next steps could include evaluating the blood brain barrier permeability of the lead nucleotide and its activity on human neurons and glia.

SciBX 6(28); doi:10.1038/scibx.2013.731
Published online July 25, 2013

Patent application filed; available for licensing

Azran, S. et al. J. Med. Chem.;
published online June 10, 2013;
Contact: Bilha Fischer, Bar-Ilan University, Ramat-Gan, Israel