Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Urinary tract infection (UTI)

Estrogen receptor

Cell culture and mouse studies suggest estradiol could help treat UTIs in postmenopausal women. In two human urothelial cell lines, estradiol increased mRNA expression of five antimicrobial peptides and intracellular uptake of bacteria compared with vehicle. In ovariectomized mice, lower estrogen levels correlated with higher bacterial proliferation in the bladder. Next steps include conducting studies to mitigate estradiol side effects by combining the hormone with other compounds.

SciBX 6(28); doi:10.1038/scibx.2013.728
Published online July 25, 2013

Unpatented; licensing status not applicable

Lüthje, P. et al. Sci. Transl. Med.; published online June 19, 2013;
doi:10.1126/scitranslmed.3005574
Contact: Annelie Brauner, Karolinska Institute, Stockholm, Sweden
e-mail:
annelie.brauner@ki.se