Thursday, July 25, 2013
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Aurora kinase A (AURKA;
myelocytomatosis viral related oncogene neuroblastoma derived
culture and mouse studies suggest AURKA inhibitors that disrupt the
AURKA-NMYC complex could help treat neuroblastomas. In NMYC-driven
neuroblastoma cell lines, AURKA inhibitors decreased NMYC levels and
proliferation compared with vehicle. In a mouse model for aggressive
neuroblastoma, AURKA inhibitors decreased tumor NMYC levels and tumor volume
compared with vehicle. Next steps include identifying additional inhibitors
and testing combinations of existing AURKA inhibitors with alternative
NMYC-targeted compounds in neuroblastoma models.
Pharmaceuticals Inc. unit of Takeda
Pharmaceutical Co. Ltd. has alisertib,
a second-generation AURKA inhibitor, in Phase III testing to treat T cell
lymphoma. The compound also is in
Phase II and Phase I testing for other cancers.
At least six other companies have AURKA inhibitors in Phase II testing or
earlier to treat various cancers.
Published online July 25, 2013
Patented by Millennium
Pharmaceuticals; licensing status unavailable
M. et al. Cancer Cell;
published online June 20, 2013;
Contact: Martin Eilers, University of Wuerzburg, Wuerzburg,
Contact: Louis Chesler, The Institute of Cancer Research,
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