This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Various

Obesity; obsessive compulsive disorder
(OCD)

Discs large homolog-associated protein 3 (DLGAP3; SAPAP3); melanocortin 4
receptor
(MC4R);

Mouse studies suggest inhibition of MC4R could help treat OCD and inhibition of SAPAP3 could help treat obesity. In a Sapap3 knockout mouse model for OCD, Mc4r knockout or intracerebroventricular infusion of a small molecule MC4R antagonist normalized compulsive grooming behaviors. In an Mc4r knockout mouse model for obesity, Sapap3 knockout reversed excessive weight gain and metabolic markers of obesity. Next steps include dissecting downstream pathways of MC4R and SAPAP3 using the same mouse models and determining whether the results extend to other OCD and obesity models.

SciBX 6(27); doi:10.1038/scibx.2013.696
Published online July 18, 2013

Unpatented; licensing status not applicable

Xu, P. et al. Proc. Natl. Acad. Sci. USA; published online June 10, 2013;
doi:10.1073/pnas.1308195110
Contact: Andrew A. Pieper, The University of Iowa, Iowa City, Iowa
e-mail:

andrew-pieper@uiowa.edu
Contact: Michael Lutter, same affiliation as above
e-mail:

michael-lutter@uiowa.edu
Contact: Robert C. Malenka, Stanford University, Stanford, Calif.
e-mail:

malenka@stanford.edu