This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Various

Atherosclerosis; hyperlipidemia

MicroRNA-30c
(miR-30c)

Mouse and cell culture studies suggest miR-30c could help treat hyperlipidemia and atherosclerosis. In mice fed a Western diet, hepatic overexpression of miR-30c decreased plasma lipid concentrations and hepatic lipoprotein production compared with overexpression of scrambled miRNA. In a mouse model for atherosclerosis, overexpression of miR-30c decreased the number and size of atherosclerotic plaques compared with overexpression of scrambled miRNA. Next steps include evaluating
miR-30c in additional animal models.

SciBX 6(27); doi:10.1038/scibx.2013.694
Published online July 18, 2013

Patent pending; available for licensing from SUNY Downstate Medical Center
Contact: David Schoenhaut, SUNY Downstate Medical Center, Brooklyn, N.Y.
e-mail:

david.schoenhaut@downstate.edu

Soh, J. et al. Nat. Med.; published online June 9, 2013;
doi:10.1038/nm.3200
Contact: M. Mahmood Hussain, SUNY Downstate Medical Center, Brooklyn, N.Y.
e-mail:

mhussain@downstate.edu