This week in therapeutics




Licensing status

Publication and contact information

Renal disease

Renal failure

Nitric oxide (NO); g-glutamyltransferase (GGT)

Ex vivo tissue studies suggest NO-generating prodrugs could help treat acute renal failure. In ex vivo rat aortic ring tissue, a lead N-hydroxyguanidine analog released NO and induced vasodilation. In the aortic ring tissue, a glutamyl prodrug of the lead compound and the renal-specific enzyme GGT increased NO release and vasodilation compared with the prodrug alone. In isolated, perfused rat kidneys, the prodrug increased vasodilation compared with the unconjugated lead compound or an inactive control compound. Next steps include testing the prodrug in models for ischemia- and sepsis-induced acute renal failure.

SciBX 6(27); doi:10.1038/scibx.2013.693
Published online July 18, 2013

Unpatented; available for partnering

Zhang, Q. et al. J. Med. Chem.; published online June 5, 2013;
Contact: Ian L. Megson, The University of The Highlands and Islands, Inverness, U.K.