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Calcium channel voltage-dependent L type-a 1C subunit (CACNA1C; Cav1.2)

Rodent and cell culture studies suggest inhibiting Cav1.2 could help treat febrile seizures. In rat hippocampal pyramidal neurons, Cav1.2 was associated with temperature-induced, seizure-related firing activity. In rat pups, the nonselective calcium channel blocker nimodipine decreased the incidence and duration of febrile seizures compared with vehicle. Next steps could include screening for Cav1.2-selective inhibitors and evaluating their effect in models for febrile seizure.
Nimodipine is a generic drug used to improve neurological outcomes after subarachnoid hemorrhage. Oral formulations of the drug are marketed by Bayer AG as Nimotop and Arbor Pharmaceuticals Inc. as Nymalize.

SciBX 6(27); doi:10.1038/scibx.2013.692
Published online July 18, 2013

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Radzicki, D. et al. J. Neurosci.; published online June 12, 2013;
Contact: Marco Martina, Northwestern University, Chicago, Ill.