This week in therapeutics

Indication

Target/marker/pathway

Summary

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Neurology

Multiple sclerosis (MS)

Mannosyl
(a-1,6-)-glycoprotein b-1,6-N-acetyl-glucosaminyltransferase isozyme B (MGAT5B)

Mouse studies suggest inhibiting MGAT5B could help treat MS. In a mouse model for chemically induced demyelination, MGAT5B knockout increased remyelination compared with no knockout. Next steps could include identifying small molecules that inhibit MGAT5B.

SciBX 6(27); doi:10.1038/scibx.2013.691
Published online July 18, 2013

Patent and licensing status unavailable

Kanekiyo, K. et al. J. Neurosci.; published online June 12, 2013;
doi:10.1523/JNEUROSCI.3137-12.2013
Contact: Naoyuki Taniguchi, RIKEN, Saitama, Japan
e-mail:

tani52@wd5.so-net.ne.jp