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Rodent and sheep studies suggest S-nitrosylation of hemoglobin in banked red blood cells (RBCs) could improve blood transfusion outcomes. In a rat model for hemorrhage, transfusion of re-nitrosylated, stored RBCs restored muscle oxygenation levels to baseline, whereas transfusion of untreated, stored RBCs did not. In two sheep models of anemia, transfusion of re-nitrosylated, stored RBCs increased muscle oxygenation compared with transfusion of untreated, stored RBCs and also improved cardiovascular and renal function. Next steps include characterizing baseline oxygenation levels in humans after receiving banked blood and comparing re-nitrosylated blood with banked blood in a clinical trial (see S-nitrosylation boon to blood transfusions, page 1).

SciBX 6(27); doi:10.1038/scibx.2013.684
Published online July 18, 2013

Multiple patent applications filed covering re-nitrosylation of
blood; licensing details available from Case Western Reserve University

Reynolds, J.D. et al. Proc. Natl. Acad. Sci. USA; published online June 24, 2013;
Contact: Jonathan S. Stamler, Case Western Reserve University, Cleveland, Ohio