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Atherosclerosis; hyperlipidemia

Variability in response to cholesterol enriched atherogenic diet (DIET1); fibroblast growth factor 19 (FGF19)

Mouse studies suggest inhibiting DIET1 could help treat atherosclerosis or hyperlipidemia. In a mouse strain previously shown to be resistant to atherosclerosis and hyperlipidemia, a loss-of-function mutation was identified in Diet1 that decreased levels of an FGF19 homolog. In normal mice, Diet1 knockout increased bile acid production and decreased cholesterol levels compared with no knockout. Next steps include using a human intestinal cell-based assay to identify DIET1 modulators.

SciBX 6(26); doi:10.1038/scibx.2013.667
Published online July 11, 2013

Findings unpatented; available for licensing

Vergnes, L. et al. Cell Metab.; published online June 4, 2013;
Contact: Karen Reue, University of California, Los Angeles, Calif.