This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Schizophrenia

Insulin-like growth factor-2 (IGF-2); insulin-like growth factor-1 receptor (IGF1R; CD221)

A mouse study suggests restoring IGF-2 could help treat schizophrenia. In mice, knockout of DiGeorge syndrome chromosomal region 8 (Dgcr8), which has been associated with schizophrenia in humans, decreased hippocampal neurogenesis and expression of Igf-2 compared with no knockout. The knockout also impaired responses in behavioral and cognitive tests. In Dgcr-/- mice, intrahippocampal administration of IGF-2 increased neurogenesis and decreased learning deficits compared with vehicle administration. Next steps include developing a system for intravascular administration of IGF-2.

SciBX 6(25); doi:10.1038/scibx.2013.633
Published online June 27, 2013

Patent application filed; available for licensing from Chubu University

Ouchi, Y. et al. J. Neurosci.;
published online May 29, 2013;
doi:10.1523/JNEUROSCI.2700-12.2013
Contact: Takashi Iwamoto, Chubu University, Kasugai, Japan
e-mail:
iwamoto@isc.chubu.ac.jp