This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes

Toll-like receptor 9 (TLR9); IL-21

In vitro and mouse studies suggest adoptive transfer of TLR9-stimulated pro-B cells could help prevent type 1 diabetes. In nonobese diabetic (NOD) mice, adoptive transfer of bone marrow cells pretreated with a TLR9 agonist delayed disease onset and decreased pancreatic and plasma levels of Il-21 compared with adoptive transfer of cells pretreated with an inactive control oligonucleotide. Ongoing work includes testing adoptive transfer of TLR9-activated pro-B cells in mouse models for other autoimmune diseases.

SciBX 6(25); doi:10.1038/scibx.2013.626
Published online June 27, 2013

Unpatented; unlicensed

Montandon, R. et al. Proc. Natl. Acad. Sci. USA; published online May 28, 2013;
doi:10.1073/pnas.1222446110
Contact: Flora Zavala, University Paris Descartes, Paris, France
e-mail:
flora.zavala@parisdescartes.fr