This week in therapeutics




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Endocrine/metabolic disease


Toll-like receptor 9 (TLR9); IL-21

In vitro and mouse studies suggest adoptive transfer of TLR9-stimulated pro-B cells could help prevent type 1 diabetes. In nonobese diabetic (NOD) mice, adoptive transfer of bone marrow cells pretreated with a TLR9 agonist delayed disease onset and decreased pancreatic and plasma levels of Il-21 compared with adoptive transfer of cells pretreated with an inactive control oligonucleotide. Ongoing work includes testing adoptive transfer of TLR9-activated pro-B cells in mouse models for other autoimmune diseases.

SciBX 6(25); doi:10.1038/scibx.2013.626
Published online June 27, 2013

Unpatented; unlicensed

Montandon, R. et al. Proc. Natl. Acad. Sci. USA; published online May 28, 2013;
Contact: Flora Zavala, University Paris Descartes, Paris, France