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Pulmonary disease

Pulmonary disease

Mucin 5B oligomeric mucus/gel-forming (MUC5B)

Patient studies suggest the rs35705950 SNP in the MUC5B promoter region could be a marker of interstitial lung disease risk. In a combined analysis of genomic data and chest CT scans from 2,633 subjects, the rs35705950 SNP in the MUC5B promoter region was associated with a 2.8-fold greater risk of interstitial lung abnormalities and a 6.3-fold greater risk of pulmonary fibrosis (p<0.001). Next steps include studying early forms of interstitial lung disease and developing intervention strategies based on decreasing MUC5B expression.

SciBX 6(24); doi:10.1038/scibx.2013.608
Published online June 20, 2013

Patent applications filed; available for licensing

Hunninghake, G.M. et al. N. Engl. J. Med.; published online May 21, 2013;
Contact: David A. Schwartz, University of Colorado Denver, Aurora, Colo.
Contact: Gary M. Hunninghake, Brigham and Women's Hospital, Boston, Mass.