Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Epilepsy

Semaphorin 4D (SEMA4D)

Cell and tissue culture studies suggest SEMA4D-Fc could be used to treat epilepsy. Sema4d-Fc is produced by conjugating the extracellular domain of mouse Sema4d to the Fc region of mouse IgG. In wild-type, cultured neurons and hippocampal brain slices, Sema4d-Fc increased formation of inhibitory GABAergic synapses compared with a control Fc. In an in vitro model for epilepsy, Sema4d-Fc decreased hyperexcitability compared with a control Fc. Next steps could include testing Sema4d-Fc in mouse models for epilepsy.

SciBX 6(24); doi:10.1038/scibx.2013.606
Published online June 20, 2013

Patented; available for licensing from the Brandeis University Office of Technology Licensing

Kuzirian, M.S. et al. J. Neurosci.; published online May 22, 2013;
doi:10.1523/JNEUROSCI.0989-13.2013
Contact: Suzanne Paradis, Brandeis University, Waltham, Mass.
e-mail:

paradis@brandeis.edu