Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Dermatology

Itch

B-type natriuretic peptide (BNP; NPPB); natriuretic peptide
receptor A
(NPR1; NPRA)

Mouse studies suggest inhibiting NPPB or NPRA could help treat itch. In mouse models for chemical-induced itch, Nppb deficiency or chemical ablation of Npra-expressing spinal neurons decreased scratching behavior compared with no Nppb deficiency or no modification of spinal neurons, respectively. In these mice, the Nppb deficiency or loss of Npra-expressing spinal neurons did not affect responses to thermal, tactile and other stimuli. Next steps could include identifying potential cardiovascular side effects of inhibiting NPPB-NPRA signaling and elucidating itch-inducing targets downstream of NPPB and NPRA.

SciBX 6(24); doi:10.1038/scibx.2013.601
Published online June 20, 2013

Unpatented; licensing status not applicable

Mishra, S.K. & Hoon, M.A. Science; published online May 24, 2013;
doi:10.1126/science.1233765
Contact: Mark A. Hoon, National Institutes of Health, Bethesda, Md.
e-mail:

mark.hoon@nih.gov