Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Ninjurin 1 (NINJ1)

Cell culture studies suggest inhibiting NINJ1 could help treat cancer. In human cancer cells, small hairpin RNA-mediated NINJ1 knockdown upregulated the tumor suppressor p53 and prevented colony formation. In cell culture, Ninj1-deficient mouse embryonic fibroblasts had higher p53 levels and showed greater senescence than nondeficient controls. Next steps could include screening for pharmacological inhibitors of Ninj1.

SciBX 6(24); doi:10.1038/scibx.2013.596
Published online June 20, 2013

Patent and licensing status unavailable

Cho, S.-J. et al. Proc. Natl. Acad. Sci. USA; published online May 20, 2013;
doi:10.1073/pnas.1221242110
Contact: Xinbin Chen, University of California, Davis, Calif.
e-mail:

xbchen@ucdavis.edu