Thursday, June 13, 2013
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In vitro and mouse studies suggest an anti-PNAG antibody
could help prevent infections from a range of pathogens. PNAG was expressed
on the surface of Candida albicans, Neisseria meningitidis, Plasmodium
species, Streptococcus pneumoniae, S. pyogenes and multiple
other pathogens. In mouse models for C. albicans, N. meningitidis,
S. pyogenes or P. burghei infection, pretreatment with the
anti-PNAG antibody F598
decreased pathogen burden and markers of disease compared with control
antibody or control serum. Ongoing work includes testing F598 against Escherichia
coli K1, Group B Streptococcus and other pathogens that cause
Alopexx Pharmaceuticals LLC
have F598 (SAR279356)
in Phase II testing to prevent bacterial infections.
Vaccine LLC has a vaccine based on deacetylated PNAG in
preclinical development to prevent bacterial infections in humans and animals
broadening infection protection, page 6).
Published online June 13, 2013
Patented by Brigham
Hospital and Beth
Israel Deaconess Medical Center; licensed to Alopexx
Pharmaceuticals LLC and Sanofi
Cywes-Bentley, C. et al.
Proc. Natl. Acad. Sci. USA; published online May 28, 2013;
Contact: Gerald B. Pier, Brigham and Women's Hospital and Harvard
Medical School, Boston, Mass.
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