Thursday, June 13, 2013
This week in
Publication and contact
In vitro and mouse studies suggest an anti-PNAG antibody
could help prevent infections from a range of pathogens. PNAG was expressed
on the surface of Candida albicans, Neisseria meningitidis, Plasmodium
species, Streptococcus pneumoniae, S. pyogenes and multiple
other pathogens. In mouse models for C. albicans, N. meningitidis,
S. pyogenes or P. burghei infection, pretreatment with the
anti-PNAG antibody F598
decreased pathogen burden and markers of disease compared with control
antibody or control serum. Ongoing work includes testing F598 against Escherichia
coli K1, Group B Streptococcus and other pathogens that cause
Alopexx Pharmaceuticals LLC
have F598 (SAR279356)
in Phase II testing to prevent bacterial infections.
Vaccine LLC has a vaccine based on deacetylated PNAG in
preclinical development to prevent bacterial infections in humans and animals
broadening infection protection, page 6).
Published online June 13, 2013
Patented by Brigham
Hospital and Beth
Israel Deaconess Medical Center; licensed to Alopexx
Pharmaceuticals LLC and Sanofi
Cywes-Bentley, C. et al.
Proc. Natl. Acad. Sci. USA; published online May 28, 2013;
Contact: Gerald B. Pier, Brigham and Women's Hospital and Harvard
Medical School, Boston, Mass.
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]