Thursday, June 13, 2013
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Phosphoinositide 3-kinase (PI3K);
homolog deleted on chromosome 10 (PTEN;
kinase B (PKB;
Mouse studies suggest AS101
could help prevent cyclophosphamide-induced depletion of
ovarian follicles, which leads to infertility. In female mice,
cyclophosphamide enhanced Pi3k-Pten-Akt signaling and decreased primordial
ovarian follicles compared with vehicle. In female mice, the Pi3k-Pten-Akt
pathway inhibitor AS101 decreased cyclophosphamide-induced follicle loss and
rescued fertility compared with saline. Next steps include evaluating the
ability of AS101 to protect ovarian follicles in nonhuman primates.
Ltd.' s AS101 is in
Phase II testing to prevent chemotherapy-associated hematological toxicity.
Cyclophosphamide is a
Published online June 13, 2013
Patented; available for
licensing from BioMAS Ltd.
Contact: Ayelet Dilion-Mashiah, BioMAS Ltd., Jerusalem, Israel
Kalich-Philosoph, L. et
al. Sci. Trans. Med.; published online May 15, 2013;
Contact: Dror Meirow, Tel Aviv University, Tel Aviv, Israel
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