Thursday, June 13, 2013
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Transforming growth factor b1 (TGFb1; TGFB1);
TGFb receptor II
Patient sample and rodent
studies suggest inhibiting TGFb1 signaling in bone
could help treat OA. Subchondral bone samples from patients with OA showed
elevated TGFb1 levels compared with samples from healthy
controls. In a mouse model for OA, deletion of Tgfbr2 decreased
severity of OA symptoms compared with no deletion. In a rat model for OA, an
antibody that blocks Tgfb signaling improved bone architecture compared with
vehicle. Next steps include clinical trials to evaluate inhibitors of TGFb1
Pharmaceutical Co. Ltd. and Shionogi
& Co. Ltd. market Esbriet
a small molecule inhibitor of proinflammatory cytokines such as tumor
necrosis factor-a (TNF-a) and IL-1b,
as well as profibrotic cytokines including platelet
derived growth factor (PDGF)
At least 11 other companies
have compounds that inhibit TGFb1 in Phase II or
earlier testing to treat various diseases.
Published online June 13, 2013
Patent application filed;
available for licensing
Zhen, G. et al. Nat.
Med.; published online May 19, 2013;
Contact: Xu Cao, Johns Hopkins University, Baltimore, Md.
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