Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Depression

Protocadherin 17 (PCDH17)

Mouse and nonhuman primate studies suggest inhibiting PCDH17 could help treat depression. In those animals, Pcdh17 was expressed in corticobasal ganglia circuits that carry signals between neurons of the cerebral cortex and the thalamus. In mice, knocking out Pcdh17 increased synaptic transmission efficacy in corticobasal ganglia circuits and decreased depressive behaviors compared with no knockout. Next steps include solving the crystal structure of the PCDH17 extracellular domain to understand its behavior across synapses.

SciBX 6(22); doi:10.1038/scibx.2013.551
Published online June 6, 2013

Unpatented; licensing status not applicable

Hoshina, N. et al. Neuron;
published online May 16, 2013;
doi:10.1016/j.neuron.2013.03.031
Contact: Tadashi Yamamoto, Okinawa Institute of Science and Technology Graduate University, Onna-son, Japan
e-mail:
tadashi.yamamoto@oist.jp