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Target/marker/pathway

Summary

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Inflammation

Inflammation

Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209)

Cell culture and mouse studies identified DC-SIGN-binding mannodendrimers that could help treat inflammatory diseases. Mannodendrimers are comprised of poly(phosphorhydrazone) dendrimers grafted with mannose units of varying length. In lipopolysaccharide (LPS)-stimulated human dendritic cells, the mannodendrimers selectively bound to DC-SIGN and decreased tumor necrosis factor-a (TNF-a) secretion compared with vehicle. In a mouse model for LPS-induced acute lung inflammation, a mannodendrimer decreased lung neutrophil recruitment compared with vehicle. Next steps could include testing the mannodendrimer in additional mouse models for inflammatory diseases.

SciBX 6(22); doi:10.1038/scibx.2013.549
Published online June 6, 2013

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Blattes, E. et al. Proc. Natl. Acad. Sci. USA; published online May 13, 2013;
doi:10.1073/pnas.1221708110
Contact: Germain Puzo, Institute of Pharmacology and Structural Biology, Toulouse, France
e-mail:
germain.puzo@ipbs.fr