This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes; obesity

Not applicable

Mouse studies suggest molecules produced by the bacterial strain Akkermansia muciniphila could help treat obesity and type 2 diabetes. In a mouse model for obesity, oral delivery of A. muciniphila normalized metabolic markers of adiposity and reversed diet-induced fasting hyperglycemia, and it decreased body weight compared with no treatment. In mouse models for diabetes and obesity, treatment with oligofructose to increase A. muciniphila abundance led to decreased total fat mass and body weight compared with no treatment. Next steps include identifying the bacterial molecules that mediate the observed effects and evaluating their therapeutic potential.

SciBX 6(21); doi:10.1038/scibx.2013.519
Published online May 30, 2013

Unpatented; licensing status undisclosed

Everard, A. et al. Proc. Natl. Acad. Sci. USA; published online May 13, 2013;
doi:10.1073/pnas.1219451110
Contact: Patrice D. Cani, Université Catholique de Louvain, Brussels, Belgium
e-mail:

patrice.cani@uclouvain.be