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Cardiovascular disease


Peptidyl arginine deiminase type IV (PADI4; PAD4)

Mouse studies suggest PAD4 inhibition could help treat or prevent thrombosis. PAD4 is required for the formation of neutrophil extracellular traps, which are components of thrombi. In a mouse model for deep vein thrombosis, thrombi formed in less than 10% of Padi4-deficient animals, whereas thrombi formed in more than 90% of wild-type animals. Padi4 knockout did not affect normal bleeding and platelet function. Next steps include developing inhibitors of PAD4.

SciBX 6(21); doi:10.1038/scibx.2013.518
Published online May 30, 2013

Patent application filed; available for licensing

Martinod, K. et al. Proc. Natl. Acad. Sci. USA; published online May 6, 2013;
Contact: Denisa D. Wagner, Harvard Medical School, Boston, Mass.