This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Lysine-specific demethylase 4A
(KDM4A; JMJD2A); jun (AP1) proto-oncogene

Cell culture and mouse studies suggest inhibiting KDM4A could help treat metastatic squamous cell carcinoma (SCC). A small hairpin RNA screen against 27 histone demethylases (HDACs) in SCC cells showed that KDM4A knockdown decreased cellular invasion and expression of AP1 target genes compared with no knockdown. In an orthotopic mouse model for SCC, shRNA against KDM4A in implanted cells decreased metastasis compared with control shRNA. Next steps include testing KDM4A inhibitors in SCC models.

SciBX 6(21); doi:10.1038/scibx.2013.513
Published online May 30, 2013

Unpatented; licensing status not applicable

Ding, X. et al. Sci. Signal.; published online April 30, 2013;
doi:10.1126/scisignal.2003884
Contact: Cun-Yu Wang, University of California, Los Angeles, Calif.
e-mail:

cunywang@ucla.edu