Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Various

Bacterial infections; inflammation

Lipopolysaccharide (LPS)

Cell culture studies suggest a cathelicidin polypeptide isolated from the skin of the frog Paa yunnanensis could help treat bacterial infections or reduce inflammation. In a panel of bacteria and fungi, cathelicidin decreased growth in 13 of 14 microorganisms at micromolar concentrations compared with saline. In mouse macrophages, cathelicidin inhibited LPS-induced production of inflammatory cytokines. Next steps could include optimizing the potency and pharmacokinetic profile of cathelicidin.

SciBX 6(20); doi:10.1038/scibx.2013.497
Published online May 23, 2013

Patent and licensing status unavailable

Wei, L. et al. J. Med. Chem.; published online April 17, 2013;
doi:10.1021/jm4004158
Contact: Ren Lai, Life Sciences College of Nanjing Agricultural University, Nanjing, China
e-mail:
rlai72@njau.edu.cn
Contact: Xiuwen Yan, same affiliation as above
e-mail:
yanxw@njau.edu.cn
Contact: Donghai Lin, Xiamen University, Xiamen, China
e-mail:
dhlin@xmu.edu.cn