Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Neurology

Histone
deacetylase 2
(HDAC2)

Mouse studies suggest inhibiting HDAC2 in the brain could help improve cognitive function in neuropsychiatric and neurodegenerative diseases. Mice with forebrain-specific disruption of Hdac2 showed better performance on tests of conditioned associative learning and had higher hippocampal synaptic function than wild-type controls. Next steps include identifying and testing brain-penetrant, selective inhibitors of HDAC2 in murine models for cognitive dysfunction.
Acetylon Pharmaceuticals Inc. has an inhibitor of HDAC1 and HDAC2 in preclinical development for thalassemia and sickle cell disease.

SciBX 6(20); doi:10.1038/scibx.2013.495
Published online May 23, 2013

Unpatented; licensing status not applicable

Morris, M.J. et al. J. Neurosci.; published online April 10, 2013;
doi:10.1523/JNEUROSCI.1001-12.2013
Contact: Lisa M. Monteggia, The University of Texas Southwestern Medical Center, Dallas, Texas
e-mail:
lisa.monteggia@utsouthwestern.edu