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Depression; pain

Regulator of G-protein
signaling 4

Mouse studies suggest modulating RGS4 activity could help enhance the efficacy of antidepressant drugs. In mice, viral vector-mediated overexpression of Rgs4 in the nucleus accumbens region of the brain increased the antidepressant and antiallodynia effects of three monoamine-targeting antidepressant drugs compared with overexpression of a control gene. In mice, knockout of Rgs4 in all tissues or specifically in the nucleus accumbens increased the antidepressant and antiallodynia effects of two non-monoamine-targeting antidepressant drugs compared with no knockout. Next steps could include screening for small molecule modulators of RGS4 activity and evaluating their effects in combination with different classes of antidepressant drugs.

SciBX 6(20); doi:10.1038/scibx.2013.494
Published online May 23, 2013

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Stratinaki, M. et al. Proc. Natl. Acad. Sci. USA; published online April 29, 2013;
Contact: Venetia Zachariou, Mount Sinai School of Medicine, New York, N.Y.