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Telomerase reverse transcriptase (TERT)

A mouse study suggests adoptive transfer of
T cells expressing a TERT-specific T cell receptor (TCR) and additional small interfering RNAs could help treat adult T cell leukemia (ATL). A retroviral vector was engineered to express both a TERT-specific TCR and siRNAs that suppressed expression of endogenous TCRs, then transduced into CD8+ T cells. In mouse models for ATL, infusion of autologous or allogeneic
T cells modified with the vector decreased tumor growth compared with infusion of unmodified cells. Next steps include determining whether the approach could be toxic to TERT-expressing normal tissues and measuring the proliferation of the adoptive T cells in vivo.

SciBX 6(20); doi:10.1038/scibx.2013.492
Published online May 23, 2013

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Miyazaki, Y. et al. Blood; published online May 2, 2013;
Contact: Hiroshi Fujiwara, Ehime University Proteo-medicine Research Center, Toon, Japan