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Publication and contact information

Endocrine/metabolic disease

Dyslipidemia; metabolic syndrome; obesity

Transcription factor EB (TFEB)

Mouse studies suggest increasing TFEB activity could help prevent dyslipidemia and associated conditions such as metabolic syndrome and obesity. Mice with liver-specific Tfeb knockout had increased peripheral adipose tissue and lipid accumulation in the liver compared with wild-type mice. In mice, adenoviral vector-induced overexpression of human TFEB prevented diet-induced obesity and decreased markers of metabolic syndrome compared with no overexpression. Next steps include testing in additional animal models for metabolic disease.

SciBX 6(18); doi:10.1038/scibx.2013.440
Published online May 9, 2013

Patent application filed; available for licensing from Fondazione Telethon

Settembre, C. et al. Nat. Cell Biol.; published online April 21, 2013;
Contact: Andrea Ballabio, Telethon Institute of Genetics and Medicine, Naples, Italy
Contact: Carmine Settembre, same affiliation as above