Thursday, May 2, 2013
This week in therapeutics
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Mouse studies suggest
radionuclide-labeled Listeria monocytogenes could help treat
metastatic pancreatic cancer. In a mouse model for metastatic pancreatic
cancer, an attenuated strain of L. monocytogenes showed greater
infection and replication in metastatic lesions than in primary tumors and
normal tissues. In the mouse model, attenuated L. monocytogenes linked
to rhenium-188 (188Re) decreased the number and size of metastatic
lesions compared with the bacterium or 188Re alone. Next steps
include testing the 188Re-labeled L. monocytogenes in
xenograft models for pancreatic cancer.
Advaxis Inc.'s Lovaxin C (ADXS11-001),
L. monocytogenes-based immunotherapy expressing HPV type 16 E7, is in
Phase II testing to treat cervical cancer and Phase I/II testing to treat
colorectal and head and neck cancers.
Aduro BioTech Inc.'s CRS-207 (ANZ-207),
a live, attenuated strain of L. monocytogenes that expresses human mesothelin,
is in Phase II testing to treat pancreatic cancer and Phase I testing to
treat mesothelioma. (See Add radioactivity to the Listeria, page 6).
Published online May 2, 2013
Patented by the Albert
Einstein College of Medicine of Yeshiva University;
available for licensing
Quispe-Tintaya, W. et
Proc. Natl. Acad. Sci. USA;
published online April 22, 2013;
Contact: Claudia Gravekamp,
Albert Einstein College of Medicine of Yeshiva University, Bronx, N.Y.
Contact: Ekaterina Dadachova,
same affiliation as above
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