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Colorectal cancer

Tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS); TNKS2

Mouse studies suggest small molecule inhibitors of TNKS and TNKS2 could be useful for treating colorectal cancer. In a mouse xenograft model for colorectal cancer, dual inhibitors of TNKS and TNKS2 decreased wingless-type MMTV integration site (WNT) signaling and tumor growth compared with vehicle. Next steps include improving tolerability, optimizing dosage and selecting a preclinical candidate.
Novartis AG has discovery-stage TNKS and TNKS2 inhibitors for various cancers.

SciBX 6(16); doi:10.1038/scibx.2013.385
Published online April 25, 2013

Patented; licensing status undisclosed

Lau, T. et al. Cancer Res.; published online March 28, 2013;
Contact: Mike Costa, Genentech Research & Early Development, South San Francisco, Calif.