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Cardiovascular disease

Myocardial infarction (MI); heart failure

Phospholipase Ce (PLCe)

Mouse studies suggest inhibiting PLCe could help prevent pathological cardiac hypertrophy and heart failure after MI. In mice subjected to transverse aortic constriction, cardiomyocyte-specific knockout of Plce decreased pathological hypertrophy compared with no knockout and protected against loss of cardiac function. Next steps could include screening for compounds that inhibit PLCe signaling.

SciBX 6(15); doi:10.1038/scibx.2013.363
Published online April 18, 2013

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Zhang, L. et al. Cell; published online March 28, 2013;
Contact: Alan V. Smrcka, The School of Medicine and Dentistry at the University of Rochester Medical Center, Rochester, N.Y.