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Renal disease

Polycystic kidney disease (PKD)

Polycystic kidney disease 1 (PKD1)

Mouse studies suggest inhibiting glycolysis could help treat autosomal dominant PKD. In Pkd1-deficient mice and in cysts from patients with PKD, expression of genes involved in glycolysis was greater than that in wild-type mice and minimally cystic human tissues, respectively. In the PKD mouse model, 2-deoxyglucose, a glucose analog that inhibits glycolysis, decreased kidney cyst numbers and kidney volume and weight compared with vehicle. Next steps include additional animal studies.

SciBX 6(14); doi:10.1038/scibx.2013.344
Published online April 11, 2013

Patent application filed; available for licensing

Rowe, I. et al. Nat. Med.; published online March 24, 2013;
Contact: Alessandra Boletta, San Raffaele Scientific Institute, Milan, Italy

Contact: Giovanna Musco, same affiliation as above