This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Inflammation

Sirtuin 6 (SIRT6); tumor necrosis factor-a (TNF-a)

In vitro and cell culture studies suggest inhibiting SIRT6 could help treat inflammation by reducing TNF-a secretion. In vitro, SIRT6 hydrolyzed long-chain fatty acid-modified histones and TNF-a about 100-200-fold more efficiently than it deacetylated histones. In cultured cells, small hairpin RNA against SIRT6 decreased levels of long-chain fatty acid-modified TNF-a and decreased secretion of the protein compared with control shRNA. Next steps include developing SIRT6-specific inhibitors and identifying other proteins regulated by this mechanism.

SciBX 6(14); doi:10.1038/scibx.2013.340
Published online April 11, 2013

Patent application filed; available for licensing

Jiang, H. et al. Nature; published online April 4, 2013;
doi:10.1038/nature12038
Contact: Hening Lin, Cornell University, Ithaca, N.Y.
e-mail:
hl379@cornell.edu

Contact: Quan Hao, The University of Hong Kong, Hong Kong, China
e-mail:
qhao@hku.hk