Thursday, April 11, 2013
This week in therapeutics
Non-small cell lung cancer
Ret proto-oncogene (RET);
oncogenic fusion protein
Preliminary results from an
investigator-initiated Phase II trial suggest small molecule RET inhibitors
could help treat RET fusion-positive lung cancers. Last year, KIF5B-RET
fusions were identified in 1%-2% of patients with NSCLC. In three RET fusion-positive
patients treated with Cometriq
two had a confirmed partial response and the third had stable disease. Next
steps include expanding the clinical trial and continuing patient follow-up.
Inc. markets Cometriq, a small molecule c-Met
receptor tyrosine kinase and VEGF
inhibitor that also inhibits RET, to treat medullary thyroid cancer.
Pharmaceuticals Inc.'s Iclusig
tyrosine kinase inhibitor that also inhibits RET, is in a
separate investigator-led Phase II trial to treat RET fusion-positive NSCLC (see
go, page 1).
Published online April 11, 2013
Patent and licensing status
Drilon, A. et al. Cancer
Discov.; published online March 26, 2013;
Contact: Naiyer A. Rizvi, Memorial Sloan-Kettering Cancer
Center, New York, N.Y.
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