This week in therapeutics




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Thalassemia; myeloproliferative disorder

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Mouse studies suggest disrupting the interaction between macrophages and erythroid cells could help treat conditions associated with disorders in erythropoiesis, such as b-thalassemia and polycythemia vera (PV). Prior studies suggested macrophages can interact with erythroid cells and regulate their proliferation and survival. In mouse models for b-thalassemia and PV, macrophage depletion restored normal erythropoiesis, normalized red blood cell counts and reversed disease pathology, whereas saline did not. Next steps include identifying the molecules responsible for the interaction between erythroid cells and macrophages and developing compounds to target such molecules.

SciBX 6(13); doi:10.1038/scibx.2013.312
Published online April 4, 2013

Unpatented; licensing status not applicable

Ramos, P. et al. Nat. Med.;
published online March 17, 2013;
Contact: Stefano Rivella, Weill Cornell Medical College, New York, N.Y.