This week in therapeutics




Licensing status

Publication and contact information

Cardiovascular disease

Cardiovascular disease

Epoxide hydrolase 2 (EPHX2; CEH)

Mouse studies suggest epoxide hydrolase inhibitors could be useful for preventing cardiac fibrosis. In two mouse models for cardiac fibrosis, epoxide hydrolase inhibitors decreased proinflammatory signaling, cardiac hypertrophy and cardiac fibrosis compared with vehicle. Next steps include preclinical development of the compounds with undisclosed industry partners.

SciBX 6(13); doi:10.1038/scibx.2013.311
Published online April 4, 2013

Patent pending; available for licensing

Sirish, P. et al. Proc. Natl. Acad. Sci. USA; published online March 14, 2013;
Contact: Nipavan Chiamvimonvat, University of California, Davis, Calif.