Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Bacterial infections

Not applicable

Two studies suggest reactive oxygen species (ROS) production may not be the major contributor to bactericidal activity. Previous studies have suggested a unifying theory of antibiotic action in which induction of ROS leads to cell death. In vitro, ampicillin or norfloxacin killed Escherichia coli grown in anaerobic conditions at rates comparable to those for bacteria grown in aerobic conditions. In titration experiments using different quantities of norfloxacin in combination with an ROS-detecting dye, a correlation was not observed between ROS and antibacterial activity. Next steps include identifying new mechanisms that explain the bactericidal effects of antibiotics.
EnBiotix Inc. is discovering compounds that increase production of ROS to treat bacterial infections.

SciBX 6(12); doi:10.1038/scibx.2013.292
Published online March 28, 2013

Patent and licensing status not applicable

Keren, I. et al. Science; published online March 8, 2013;
doi:10.1126/science.1232688
Contact: Kim Lewis, Northeastern University, Boston, Mass.
e-mail:

k.lewis@neu.edu

Liu, Y. & Imlay, J.A. Science; published online March 8, 2013;
doi:10.1126/science.1232751
Contact: James A. Imlay, University of Illinois at Urbana-Champaign,
Urbana, Ill.
e-mail:

jimlay@illinois.edu