This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Various

Cardiovascular disease; neurology

AMP-activated protein kinase (AMPK); toll-like receptor 9 (TLR9)

Cell culture studies suggest activating TLR9 could help protect cardiomyocytes and neurons from stress-induced damage. In cultured cardiomyocytes, a synthetic TLR9 ligand increased survival under hypoxia-induced stress compared with vehicle. In cultured neurons, the TLR9 ligand increased AMPK activation and decreased
H2O2-induced cell death compared with vehicle. Next steps include testing the protective effects of activating TLR9 in in vivo models.

SciBX 6(11); doi:10.1038/scibx.2013.270
Published online March 21, 2013

Unpatented; licensing status not applicable

Shintani, Y. et al. Proc. Natl. Acad. Sci. USA; published online March 11, 2013;
doi:10.1073/pnas.1219243110
Contact: Ken Suzuki, Queen Mary, University of London, London, U.K.
e-mail:
ken.suzuki@qmul.ac.uk

Contact: Yasunori Shintani, same affiliation as above
e-mail:
y.shintani@qmul.ac.uk