This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Bacterial infection; herpes simplex virus (HSV)

Interferon-e (IFNE; IFNe)

Mouse studies suggest increasing IFNE might help prevent sexually transmitted infections. In mouse models for HSV infection, IFNE-deficient mice had severe genital lesions and greater virus levels in vaginal tissues, spinal cord and brain stem than wild-type mice. In mouse models for Chlamydia muridarum infection, IFNE-deficient mice had higher vaginal and uterine bacteria levels than wild-type mice. In the Chlamydia infection mouse model, intravaginal pretreatment with IFNE six hours before challenge protected against bacterial infection. Next steps could include testing the protective effects of IFNE treatment in additional models for sexually transmitted infections.

SciBX 6(11); doi:10.1038/scibx.2013.267
Published online March 21, 2013

Patent and licensing status unavailable

Fung, K.Y. et al. Science; published online March 1, 2013;
doi:10.1126/science.1233321
Contact: Paul J. Hertzog, Monash University, Clayton, Victoria, Australia
e-mail:
paul.hertzog@monash.edu