This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Colorectal cancer

Prion protein (PRNP; PrP; CD230)

Patient sample and mouse studies suggest inhibiting PRNP could help treat metastatic colorectal cancer (CRC). In primary tumor samples from patients with CRC, increased PRNP expression in tumors was associated with increased risk of metastasis and decreased survival. In two mouse xenograft models for patient-derived metastatic CRC, animals implanted with PRNP+ CRC stem cells showed higher rates of liver metastasis than mice that received PRNP- CRC stem cells. In one of the mouse models, PRNP-targeting antibodies decreased metastasis and tumor weight compared with control IgG. Next steps include testing the antibodies in mouse models for other cancer types.

SciBX 6(11); doi:10.1038/scibx.2013.261
Published online March 21, 2013

Patent and licensing status undisclosed

Du, L. et al. Cancer Res.; published online Feb. 15, 2013;
doi:10.1158/0008-5472.CAN-12-3759
Contact: Quan Chen, Chinese Academy of Sciences, Beijing, China
e-mail:
chenq@ioz.ac.cn