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Colorectal cancer

Prion protein (PRNP; PrP; CD230)

Patient sample and mouse studies suggest inhibiting PRNP could help treat metastatic colorectal cancer (CRC). In primary tumor samples from patients with CRC, increased PRNP expression in tumors was associated with increased risk of metastasis and decreased survival. In two mouse xenograft models for patient-derived metastatic CRC, animals implanted with PRNP+ CRC stem cells showed higher rates of liver metastasis than mice that received PRNP- CRC stem cells. In one of the mouse models, PRNP-targeting antibodies decreased metastasis and tumor weight compared with control IgG. Next steps include testing the antibodies in mouse models for other cancer types.

SciBX 6(11); doi:10.1038/scibx.2013.261
Published online March 21, 2013

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Du, L. et al. Cancer Res.; published online Feb. 15, 2013;
Contact: Quan Chen, Chinese Academy of Sciences, Beijing, China