This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Nicotinamide N-methyltransferase (NNMT)

Cell culture studies suggest inhibiting NNMT could help treat cancer. Aggressive cancer cell lines showed higher NNMT levels and NNMT activity than nonaggressive cancer cell lines. In aggressive cancer cell lines, knockdown of NNMT decreased expression of multiple cancer-associated genes and invasiveness compared with no knockdown. Next steps include developing NNMT inhibitors and testing them in preclinical cancer models.

SciBX 6(11); doi:10.1038/scibx.2013.259
Published online March 21, 2013

Unpatented; licensing status not applicable

Ulanovskaya, O.A. et al. Nat. Chem. Biol.; published online March 3, 2013;
doi:10.1038/nchembio.1204
Contact: Benjamin F. Cravatt, The Scripps Research Institute, La Jolla, Calif.
e-mail:
cravatt@scripps.edu