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Migraine; pain

Caspase-1 (CASP1); high mobility group box 1 (HMGB1); NF-kB; pannexin 1

Mouse studies suggest inhibiting PANX1 in neurons could help treat migraine aura and headache. In the mouse brain, a migraine-linked electrophysiological phenomenon called cortical spreading depression (CSD) opened neuronal Panx1 channels and activated Casp1, which led to Hmgb1 release in neurons and Nf-kb activation in astrocytes. In the mouse brain, PANX1 channel blockers and small interfering RNA-mediated knockdown of Panx1 inhibited the CSD-induced signaling cascade, whereas vehicle and control siRNA did not. Next steps could include evaluating the behavioral effects of inhibiting PANX1 in animal models for migraine.

SciBX 6(10); doi:10.1038/scibx.2013.243
Published online March 14, 2013

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Karatas, H. et al. Science;
published online March 1, 2013;
Contact: Turgay Dalkara, Hacettepe University, Ankara, Turkey