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Cardiovascular disease

Myocardial infarction (MI)

MicroRNA-34a (miR-34a); protein phosphatase 1 regulatory subunit 10

Patient tissue and mouse studies suggest inhibiting miR-34a or increasing PPP1R10 levels could help improve post-MI recovery. In a mouse model for MI, an miR-34a-targeting antagomir increased Ppp1r10 levels in the heart, decreased cardiac cell death and fibrosis and led to better cardiac contractile function compared with a control antagomir. In the same model, vector-mediated expression of Ppp1r10 prevented cardiac contractile dysfunction and decreased cardiomyocyte apoptosis compared with what was seen using control vector. Next steps include testing the effects of inhibiting miR-34a in genetic mouse models and large animals models.

SciBX 6(10); doi:10.1038/scibx.2013.237
Published online March 14, 2013

Patent application filed; unlicensed

Boon, R.A. et al. Nature;
published online Feb. 20, 2013;
Contact: Stefanie Dimmeler, Goethe University Frankfurt, Frankfurt, Germany