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Cardiovascular disease


Endothelial cell nitric oxide synthase 3 (NOS3; eNOS); regulator of G-protein signaling 4 (RGS4)

In vitro and mouse studies suggest inhibiting eNOS or increasing RGS4 could help prevent cardiac hypertrophy. In a mouse model for angiogenesis-driven myocardial hypertrophy, Rgs4 expression was lower and eNos-produced NO was greater than that seen in normal mice. In the same mouse model, Rgs4 overexpression or eNos inhibition prevented hypertrophy. Next steps include studying the mechanism in pathological hypertrophy and myocardial ischemia.

SciBX 6(10); doi:10.1038/scibx.2013.236
Published online March 14, 2013

Patent application filed; available for licensing

Jaba, I.M. et al. J. Clin. Invest.;
published online March 1, 2013;
Contact: Daniela Tirziu, Yale School of Medicine, New Haven, Conn.