Thursday, March 14, 2013
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In vitro and mouse studies identified variants of IL17RA
that could help treat plaque psoriasis. In cell-based assays, soluble,
mutated versions of IL17RA bound IL-17A and decreased IL-17A-induced
secretion of inflammatory cytokines from human fibroblast cells compared with
the soluble, wild-type receptor. In a mouse model for plaque psoriasis,
subcutaneous injection of an IL17RA variant improved skin recovery with
potency comparable to that of dexamethasone, a generic anti-inflammatory
steroid. Next steps include preclinical testing of the compounds in
additional autoimmune indications.
Inc. and AstraZeneca
plc have brodalumab, a humanized mAb against
IL17RA, in Phase III testing to treat psoriasis.
At least two other companies have inhibitors or antibodies targeting IL17RA
in Phase II testing or earlier to treat psoriasis.
Published online March 14, 2013
Patent application filed;
available for licensing
Zaretsky, M. et al.
published online Feb. 21, 2013;
Contact: Amir Aharoni, Ben-Gurion University of the Negev,
Be'er Sheva, Israel
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